By bus
It is very easy to get to Blumenau by bus. There are several interstate companies with regular lines to Blumenau and region. A trip from São Paulo takes about 10 hours and costs about R$100,00 US$45,00 one-way. The bus station is open 24 hours a day and has showers free bathrooms and a diner however those are very old right now and very dirty, and only snacks are available and the bus station whose is very dangerous indeed. It is served by urban buses to PROEB downtown and Fortaleza neighborhood Terminals. There are also taxis, which would take you downtown for about R$15,00 US$8,50.
Some companies in Blumenau Bus Station:
Auto Viação Catarinense Phone: +55 (47 3323-5082)
Empresa Nossa Senhora da Penha Phone: +55 (47 3323-3224)
Empresa União Transportes Phone: +55 (47 3323-6363)
By car
If you are not far away, you can come by car. The main road in the coast of the State is BR-101, but there is no way to get into Blumenau directly through this road. You will have to use either BR-470 which is very dangerous,or SC-470, known as Rodovia Governador Jorge Lacerda, which goes through the cities of ItajaÃ, Ilhota and Gaspar. This road is not as fast as BR-470, but it's much safer, has less trucks and it is better illuminated at night. You still have an option, using SC-486, which goes to Brusque, a nearby city, and then from there to Gaspar and Blumenau.
If you come from the West Western Santa Catarina, Northern Rio Grande do Sul, Southwestern Parana, Argentina or Paraguay, you have to take highway BR-282, after Lages, enter to Otacilio Costa and there you'll eventually end up at BR-470, where you'll have to take the East direction, towards Rio do Sul and eventually to Blumenau.